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A Volcano plot of the 86 MPQC genes in PDAC tumor tissues (TCGA, n = 179) and peri-tumoral pancreatic tissues (GTEx, n = 171). The upregulated genes are marked in red; the downregulated genes are marked in blue (|Log 2 FC| ≥ 1.5 & P < 0.05). The heat maps show the mRNA levels of the 23 significant DEGs. *, statistically significant, analyzed by one-way ANOVA. B Comparison of mRNA levels of 23 DEGs in normal and tumor pancreatic ductal cells at the single cell level (GEO accession number: GSE93326 ). *, statistically significant, analyzed by one-way ANOVA. C Correlation analysis of c-Myc and 23 DEGs in PDAC tissues (TCGA, n = 179). Representative IHC-staining images (left panel) and IHC scores (right panel) for GRPEL1 ( D ) and c-Myc ( E ) in 67 paired PDAC tissues. F Co-expression analyses of c-Myc and GRPEL1 in local PDAC tissues. G mRNA expression analysis of c-Myc and GRPEL1 in PANC-1, PaTu-8988t, and HEK-293T cells transfected with a control siRNA or c-Myc siRNA. Immunoblotting analysis of c-Myc and GRPEL1 in HEK-293T, PANC-1 and PaTu-8988t cells transfected with a control siRNA or c-Myc s iRNA ( H ), or in cells with or without c-Myc overexpression ( I ). GAPDH was used as an internal control. J , K Luciferase reporter assay in PaTu-8988t cells with modulated c-Myc expression. Left panels: immunoblotting analysis of c-Myc upon depletion ( J ) or overexpression ( K ). GAPDH was used as a loading control. L ChIP-qPCR analyses were performed with an anti-IgG <t>or</t> <t>an</t> <t>anti-c-Myc</t> antibody in PaTu-8988t cells. The c-Myc binding sites on GRPEL1 promoters were predicted by the JASPAR database ( https://jaspar2020.genereg.net ) (left panel). qPCR analyses were performed with primers targeting the region from −1500 bp to the transcription start site (TSS) of the GRPEL1 promoter. The red box indicates the predicted c-Myc binding site. Data are presented as means ± SEM for bar graphs from at least three independent experiments. Representative images from three independent biological replicates are shown.
Anti C Myc, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti c myc - by Bioz Stars, 2026-06
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Image Search Results


A Volcano plot of the 86 MPQC genes in PDAC tumor tissues (TCGA, n = 179) and peri-tumoral pancreatic tissues (GTEx, n = 171). The upregulated genes are marked in red; the downregulated genes are marked in blue (|Log 2 FC| ≥ 1.5 & P < 0.05). The heat maps show the mRNA levels of the 23 significant DEGs. *, statistically significant, analyzed by one-way ANOVA. B Comparison of mRNA levels of 23 DEGs in normal and tumor pancreatic ductal cells at the single cell level (GEO accession number: GSE93326 ). *, statistically significant, analyzed by one-way ANOVA. C Correlation analysis of c-Myc and 23 DEGs in PDAC tissues (TCGA, n = 179). Representative IHC-staining images (left panel) and IHC scores (right panel) for GRPEL1 ( D ) and c-Myc ( E ) in 67 paired PDAC tissues. F Co-expression analyses of c-Myc and GRPEL1 in local PDAC tissues. G mRNA expression analysis of c-Myc and GRPEL1 in PANC-1, PaTu-8988t, and HEK-293T cells transfected with a control siRNA or c-Myc siRNA. Immunoblotting analysis of c-Myc and GRPEL1 in HEK-293T, PANC-1 and PaTu-8988t cells transfected with a control siRNA or c-Myc s iRNA ( H ), or in cells with or without c-Myc overexpression ( I ). GAPDH was used as an internal control. J , K Luciferase reporter assay in PaTu-8988t cells with modulated c-Myc expression. Left panels: immunoblotting analysis of c-Myc upon depletion ( J ) or overexpression ( K ). GAPDH was used as a loading control. L ChIP-qPCR analyses were performed with an anti-IgG or an anti-c-Myc antibody in PaTu-8988t cells. The c-Myc binding sites on GRPEL1 promoters were predicted by the JASPAR database ( https://jaspar2020.genereg.net ) (left panel). qPCR analyses were performed with primers targeting the region from −1500 bp to the transcription start site (TSS) of the GRPEL1 promoter. The red box indicates the predicted c-Myc binding site. Data are presented as means ± SEM for bar graphs from at least three independent experiments. Representative images from three independent biological replicates are shown.

Journal: Cell Death & Disease

Article Title: c-Myc/GRPEL1 maintains fatty acid synthesis via FASN to support PDAC cell proliferation

doi: 10.1038/s41419-026-08439-0

Figure Lengend Snippet: A Volcano plot of the 86 MPQC genes in PDAC tumor tissues (TCGA, n = 179) and peri-tumoral pancreatic tissues (GTEx, n = 171). The upregulated genes are marked in red; the downregulated genes are marked in blue (|Log 2 FC| ≥ 1.5 & P < 0.05). The heat maps show the mRNA levels of the 23 significant DEGs. *, statistically significant, analyzed by one-way ANOVA. B Comparison of mRNA levels of 23 DEGs in normal and tumor pancreatic ductal cells at the single cell level (GEO accession number: GSE93326 ). *, statistically significant, analyzed by one-way ANOVA. C Correlation analysis of c-Myc and 23 DEGs in PDAC tissues (TCGA, n = 179). Representative IHC-staining images (left panel) and IHC scores (right panel) for GRPEL1 ( D ) and c-Myc ( E ) in 67 paired PDAC tissues. F Co-expression analyses of c-Myc and GRPEL1 in local PDAC tissues. G mRNA expression analysis of c-Myc and GRPEL1 in PANC-1, PaTu-8988t, and HEK-293T cells transfected with a control siRNA or c-Myc siRNA. Immunoblotting analysis of c-Myc and GRPEL1 in HEK-293T, PANC-1 and PaTu-8988t cells transfected with a control siRNA or c-Myc s iRNA ( H ), or in cells with or without c-Myc overexpression ( I ). GAPDH was used as an internal control. J , K Luciferase reporter assay in PaTu-8988t cells with modulated c-Myc expression. Left panels: immunoblotting analysis of c-Myc upon depletion ( J ) or overexpression ( K ). GAPDH was used as a loading control. L ChIP-qPCR analyses were performed with an anti-IgG or an anti-c-Myc antibody in PaTu-8988t cells. The c-Myc binding sites on GRPEL1 promoters were predicted by the JASPAR database ( https://jaspar2020.genereg.net ) (left panel). qPCR analyses were performed with primers targeting the region from −1500 bp to the transcription start site (TSS) of the GRPEL1 promoter. The red box indicates the predicted c-Myc binding site. Data are presented as means ± SEM for bar graphs from at least three independent experiments. Representative images from three independent biological replicates are shown.

Article Snippet: The primary antibodies, including anti-c-Myc (67447-1-lg), anti-GRPEL1 (12720-1-AP), and anti-FASN (10624-2-AP), were purchased from Wuhan Sanying Biotechnology (ProteinTech, Wuhan, China).

Techniques: Comparison, Single Cell, Immunohistochemistry, Expressing, Transfection, Control, Western Blot, Over Expression, Luciferase, Reporter Assay, ChIP-qPCR, Binding Assay